Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)
Xitong Zhao, Pengqin Wang
Abstract
MicroRNA‑155 (miR‑155), a highly conserved non‑coding RNA, serves a pivotal role in the initiation and progression of cardiovascular and cerebrovascular diseases (CCVDs) through the modulation of target gene expression. miR‑155 contributes to the pathogenesis of conditions such as atherosclerosis, myocardial infarction, heart failure, hypertension and stroke, with mechanisms involving the regulation of endothelial function, inflammatory responses, oxidative stress, apoptosis and fibrosis. These findings suggest its potential as a biomarker. The present review provides a comprehensive overview of the biogenesis, regulation and biological functions of miR‑155, highlights its molecular mechanisms in CCVD progression, and examines current advances in therapeutic strategies targeting miR‑155, offering insights into the pathological mechanisms and precision treatment approaches for CCVDs.