Ginsenoside 20(S)-Rg3 upregulates SQLE to reprogram cholesterol metabolism of ovarian cancer cells
Fang He, Yuanyuan Zhou, Jing Fu, ShiXue Chang, Xi Cui, Zhaozu Feng, Le Zhao, Li Xu
Abstract
, as well as cell migration, invasion, and cholesterol synthesis. 20(S)-Rg3 enhanced SQLE expression by downregulating HIF-1α. Co-immunoprecipitation confirmed the interaction between SQLE and farnesyl-diphosphate farnesyltransferase 1 (FDFT1), another rate-limiting enzyme in cholesterol metabolism. These findings suggest that 20(S)-Rg3 exerts anti-ovarian cancer effects by HIF-1α/SQLE/FDFT1 to reprogram cholesterol metabolism.
Topics & Concepts
GinsenosideOvarian cancerCancer researchCholesterolLipid metabolismCancerChemistryPharmacologyBiologyInternal medicineMedicineBiochemistryPathologyGinsengAlternative medicineGinseng Biological Effects and ApplicationsCancer, Lipids, and MetabolismLipid metabolism and disorders