Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance
Wenhu Zhan, Da‐Qiang Li, Shubha Bevkal Subramanyaswamy, Yi Jing Liu, Changmei Yang, Hao Zhang, Jacob Harris, Rong Wang, Songbiao Zhu, Hedy Rocha, Julian Sherman, Junling Qin, Mikayla Herring, Nelson V. Simwela, Andrew P. Waters, George Sukenick, Liwang Cui, Ana Rodrı́guez, Haiteng Deng, Carl Nathan, Laura A. Kirkman, Gang Lin
Topics & Concepts
ProteasomePlasmodium falciparumMoietyProteaseUbiquitinCell biologyPharmacophoreDrug resistanceMode of actionBiologyMalariaChemistryBiochemistryMicrobiologyEnzymeStereochemistryImmunologyGeneMalaria Research and ControlMosquito-borne diseases and controlHIV/AIDS drug development and treatment