Litcius/Paper detail

Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance

Wenhu Zhan, Da‐Qiang Li, Shubha Bevkal Subramanyaswamy, Yi Jing Liu, Changmei Yang, Hao Zhang, Jacob Harris, Rong Wang, Songbiao Zhu, Hedy Rocha, Julian Sherman, Junling Qin, Mikayla Herring, Nelson V. Simwela, Andrew P. Waters, George Sukenick, Liwang Cui, Ana Rodrı́guez, Haiteng Deng, Carl Nathan, Laura A. Kirkman, Gang Lin

2023Cell chemical biology20 citationsDOIOpen Access PDF

Topics & Concepts

ProteasomePlasmodium falciparumMoietyProteaseUbiquitinCell biologyPharmacophoreDrug resistanceMode of actionBiologyMalariaChemistryBiochemistryMicrobiologyEnzymeStereochemistryImmunologyGeneMalaria Research and ControlMosquito-borne diseases and controlHIV/AIDS drug development and treatment