Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice
Mingdong Yu, Chao Qin, Pei Li, Yingli Zhang, Ying Wang, Jing Zhang, Dedong Li, Huixing Wang, Yuechun Lu, Keliang Xie, Yang Yu, Yonghao Yu
Topics & Concepts
MethyltransferaseBrain-derived neurotrophic factorNeurotrophic factorsMorris water navigation taskNeuroinflammationDNA methylationMethylationSynaptic plasticityBiologyInternal medicineHippocampal formationEndocrinologyMedicineChemistryInflammationGene expressionBiochemistryGeneReceptorIntensive Care Unit Cognitive DisordersHydrogen's biological and therapeutic effectsFamily and Patient Care in Intensive Care Units