Mitophagy in Yeast: Decades of Research
Ingrid Bhatia‐Kiššová, Nadine Camougrand
Abstract
Mitophagy, the selective degradation of mitochondria by autophagy, is one of the most important mechanisms of mitochondrial quality control, and its proper functioning is essential for cellular homeostasis. In this review, we describe the most important milestones achieved during almost 2 decades of research on yeasts, which shed light on the molecular mechanisms, regulation, and role of the Atg32 receptor in this process. We analyze the role of ROS in mitophagy and discuss the physiological roles of mitophagy in unicellular organisms, such as yeast; these roles are very different from those in mammals. Additionally, we discuss some of the different tools available for studying mitophagy.
Topics & Concepts
MitophagyAutophagyMitochondrionYeastBiologyCell biologyModel organismComputational biologyGeneticsGeneApoptosisAutophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsPlant Gene Expression Analysis