Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting
Hawley Kunz, Jessica M. Dorschner, Taylor E. Berent, Thomas J. Meyer, Xuewei Wang, Aminah Jatoi, Rajiv Kumar, Ian R. Lanza
Abstract
-monomethyl-l-arginine, in tumor-bearing mice compared with control mice. Compared with healthy controls, human cancer patients were also found to have higher levels of ADMA in the skeletal muscle. Treatment of C2C12 myotubes with ADMA impaired protein synthesis and reduced mitochondrial protein quality. These results suggest that increased levels of ADMA and mitochondrial changes may contribute to impaired muscle protein synthesis in cancer cachexia and could point to novel therapeutic targets by which to mitigate cancer cachexia.
Topics & Concepts
WastingMuscle proteinChemistryCancerMedicineBiochemistryInternal medicineSkeletal muscleMuscle metabolism and nutritionMuscle Physiology and DisordersNutrition and Health in Aging