Dysregulated Sp1/miR-130b-3p/HOXA5 axis contributes to tumor angiogenesis and progression of hepatocellular carcinoma
Yadi Liao, Chenwei Wang, Zhiwen Yang, Wenwu Liu, Yichuan Yuan, Kai Li, Yuanping Zhang, Yongjin Wang, Yunxing Shi, Yuxiong Qiu, Dinglan Zuo, Wei He, Jiliang Qiu, Xin‐Yuan Guan, Yunfei Yuan, Binkui Li
Abstract
: This study showed that a dysregulation in the Sp1/miR-130b-3p/HOXA5 axis contributed to HCC progression and angiogenesis, and that HOXA5 can be considered as a promising therapeutic target for treating HCC.
Topics & Concepts
Hepatocellular carcinomaAngiogenesisCancer researchmicroRNATumor progressionMedicinePathologyOncologyBiologyInternal medicineCancerGeneGeneticsMicroRNA in disease regulationCancer-related molecular mechanisms researchCancer Mechanisms and Therapy