Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration
Qinfang Liu, Judith Bautista-Gomez, Daniel A. Higgins, Jianzhong Yu, Yulan Xiong
Abstract
model of PD. Together, our findings provide a mechanistic link between LRRK2, AP2, and endocytosis in the pathogenesis of PD.
Topics & Concepts
EndocytosisNeurodegenerationPhosphorylationLRRK2ClathrinCell biologyDopaminergicKinasePinocytosisBiologyNeuroscienceChemistryParkinson's diseaseMedicineDopamineInternal medicineDiseaseBiochemistryReceptorCellular transport and secretionParkinson's Disease Mechanisms and TreatmentsGenetic Neurodegenerative Diseases