Differential expression of full-length and NH<sub>2</sub> terminally truncated FAM134B isoforms in normal physiology and cancer
Umur Keles, Evin İşcan, Huriye Erbak Yılmaz, Gökhan Karakülah, Aslı Süner, Erhan Bal, Nilgun Tasdemir, Ayşe Derya Cavga, Umut Ekin, Zeynep Mutlu, Sila Kahyaoglu, Muhittin A. Serdar, Neşe Atabey, Mehmet Öztürk
2020American Journal of Physiology-Gastrointestinal and Liver Physiology22 citationsDOIOpen Access PDF
Abstract
We reported tissues expressing FAM134B-2 such as the kidney, muscle, heart, and pancreas, some of which exhibit stimulated expression upon nutrient starvation. We also demonstrated the effect of Fam134b deletion during ad libitum and starvation conditions. Resistance to weight loss and hypocalcemia, accompanied by an increase in serum albumin and α-amylase levels, indicate critical roles of Fam134b in physiology. Furthermore, the differential expression of FAM134B isoforms was shown to be significantly dysregulated in human cancers.
Topics & Concepts
BiologyPancreasInternal medicineGene isoformEndocrinologyCancer researchMedicineGeneBiochemistryPancreatic function and diabetesAutophagy in Disease and TherapyAdenosine and Purinergic Signaling