Rapid access to C2-quaternary 3-methyleneindolines<i>via</i>base-mediated post-Ugi Conia-ene cyclization
Shuang Zhao, Yi He, Feiyu Gao, Yue Wei, Jiawei Zhang, Mengxiao Chen, Yunyun Gao, Yuan Zhang, Jun‐Yan Liu, Zufeng Guo, Zhenghua Li, Shenyou Nie
Abstract
-dig "Conia-ene"-type cyclization has been disclosed. The mechanism study indicates that an intramolecular hydrogen bond may play a vital role in this process. The antiproliferative evaluation of cancer cell lines reveals that this protocol provides practical use in the green synthesis of bioactive compound libraries.
Topics & Concepts
Ene reactionChemistryCombinatorial chemistryIntramolecular forceBase (topology)StereochemistryMathematicsMathematical analysisMicrobial Natural Products and BiosynthesisChemical Synthesis and AnalysisMulticomponent Synthesis of Heterocycles