Natural resourced polysaccharides: Preparation, purification, structural elucidation, structure-activity relationships and regulating intestinal flora, a system review
Di Han, Le Yang, Qichao Liang, Hui Sun, Ye Sun, Guangli Yan, Xiwu Zhang, Ying Han, Xiaoyu Wang, Xijun Wang, Xijun Wang, Xijun Wang
Abstract
Natural resourced polysaccharides (NRPs), as metabolites synthesized during activity of organisms, widely present in animal cell membranes or plant and microbial cell walls. NRPs have garnered extensive attention in the fields of medicine, foods, and farming owing to their distinct bioactivities and structural diversity. Despite the burgeoning growth in NRPs research, the available literature focuses primarily on a review of specific polysaccharides, necessitating an urgent need for a comprehensive summary of NRPs to offer readers a whole landscape of current advancements in NRPs research. Based on this, this article comprehensively reviews the latest research progress regarding preparation, purification, structure elucidation, structure-activity relationships and regulation of intestinal flora of NRPs in electronic databases, such as PubMed, Wiley, ScienceDirect and Web of Science from last 5 years. This review analyzes the effects of various extraction techniques on NRPs and also delves into the intrinsic correlation between the biological activity and structure of NRPs, highlighting that chemical modification can enhance their structural diversity and confer novel or improved biological functions. Moreover, this article extensively explores the application of NRP in promoting intestinal microecology balance, underscoring its significant potential as a probiotic initiator. This review lays a solid theoretical foundation for the future research and development of NRPs. • The methods, principles and applications of preparation, purification and structure elucidation of natural resourced polysaccharides were introduced. • The structure-activity relationships, chemical modification methods and the mechanism of regulating intestinal flora of natural resourced polysaccharides were discussed. • The reader can quickly and comprehensively understand natural resourced polysaccharides research current state.