Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4
Giorgia Colombo, Cristina Travelli, Chiara Porta, Armando A. Genazzani
Abstract
STAT1/3 phosphorylation. Importantly, the secretion of eNAMPT promotes the chemotactic recruitment of myeloid cells, therefore providing a potential positive feedback loop to foster inflammation. Last, we report that these events are independent of the activation of TLR4, the only eNAMPT receptor that has hitherto been recognized, prompting the knowledge that other receptors are involved.
Topics & Concepts
Nicotinamide phosphoribosyltransferaseInflammationMonocyteInternal medicineImmune systemTLR4EndocrinologyInnate immune systemNAD+ kinaseReceptorMedicineCancer researchBiologyChemistryImmunologyEnzymeBiochemistryImmune cells in cancerInflammasome and immune disordersImmune Cell Function and Interaction