Determination of the solubility of rivaroxaban (anticoagulant drug, for the treatment and prevention of blood clotting) in supercritical carbon dioxide: Experimental data and correlations
Gholamhossein Sodeifian, Mohammad Mahdi Behvand Usefi, Fariba Razmimanesh, Armin Roshanghias
Abstract
Supercritical processes are utilized in pharmaceutical, chemical, agricultural and food industries. To design the micro or nanoparticles formation processes via a supercritical fluid (SCF), it is necessary to have available the solubility data of a solid solute in a solvent such as supercritical carbon dioxide (SC-CO2). In this article, the solubility of rivaroxaban (anticoagulant drug, for the treatment and prevention of blood clotting) in SC-CO2 was investigated for the first time. Six semi-empirical models (Chrastil, Bartle, Jouyban, Garlapati and Madras, and Sodeifian) and two equation of states (EoSs) including Peng-Robinson (PR) and Soave-Redlich-Kwong (SRK) with twin-parametric van der Waals (vdW2) and covolume dependent (CVD) mixing rules were used to examine the correlation of drug solubility data. The best performance was obtained by semi-empirical Jouyban model (Average absolute relative deviation (AARD = 12.436 %)) and PR-vdW2 EoS (AARD = 5.104 %). Total and vaporization enthalpies were calculated 43.617 KJ.mol−1 and 63.288 KJ.mol−1, respectively.