Prostaglandin E2 and Its Receptor EP2 Modulate Macrophage Activation and Fusion <i>in Vitro</i>
Leila Saleh, Casey Vanderheyden, Andrew Frederickson, Stephanie J. Bryant
Abstract
expression with the EP2 agonist returned to levels that were not different from controls. This study identified that PGE2 attenuates classically activated macrophages and macrophage fusion through distinct EP receptors, while targeting EP2 is able to attenuate both. In summary, this study identified EP2 as a potential therapeutic target for reducing the FBR to biomaterials.
Topics & Concepts
Prostaglandin E2 receptorForeign-body giant cellAgonistTumor necrosis factor alphaReceptorProstaglandin E2Cell biologyLipopolysaccharideMacrophageEndocrinologyStimulationInternal medicineBiologyChemistryIn vitroMedicineBiochemistryPathologyInflammatory mediators and NSAID effectsPeptidase Inhibition and AnalysisAsthma and respiratory diseases