Minimally invasive implantation and decreased inflammation reduce osteoinduction of biomaterial
Zifan Zhao, Qin Zhao, Bin Gu, Chengcheng Yin, Kailun Shen, Hua Tang, Haibin Xia, Xiaoxin Zhang, Yanbing Zhao, Xiangliang Yang, Yufeng Zhang
Abstract
From experimental research and clinical surgery, this study discovered that the T cells are indispensable in the ectopia ossification mediated by osteoinductive materials, put forward and confirmed the surgery method as a key variable factor restricting the application effect of biological materials, enriched the key mechanism of adaptive immunity in osteoimmunomodulation, and laid a theoretical foundation for the development of osteoinductive materials and bone tissue regeneration.
Topics & Concepts
Mesenchymal stem cellImmune systemBiomaterialInflammationOsseointegrationBiomedical engineeringCell biologyChemistryImmunologyImplantCancer researchMedicineBiologySurgeryHeterotopic Ossification and Related ConditionsMesenchymal stem cell researchConnective tissue disorders research