Mechanochemical Rules for Shape-Shifting Filaments that Remodel Membranes
Billie Meadowcroft, Ivan Palaia, Anna-Katharina Pfitzner, Aurélien Roux, Buzz Baum, Anđela Šarić
Abstract
The sequential exchange of filament composition to increase filament curvature was proposed as a mechanism for how some biological polymers deform and cut membranes. The relationship between the filament composition and its mechanical effect is lacking. We develop a kinetic model for the assembly of composite filaments that includes protein-membrane adhesion, filament mechanics and membrane mechanics. We identify the physical conditions for such a membrane remodeling and show this mechanism of sequential polymer assembly lowers the energetic barrier for membrane deformation.
Topics & Concepts
Protein filamentMembraneMembrane curvatureCurvatureMaterials sciencePolymerMechanism (biology)BiophysicsDeformation (meteorology)AdhesionChemical physicsMechanicsChemistryComposite materialPhysicsBiologyVesicleGeometryMathematicsBiochemistryQuantum mechanicsCellular transport and secretionProtein Structure and DynamicsForce Microscopy Techniques and Applications