Measurement and Correlation for Solubility of <i>Myo</i>-inositol in Five Pure and Four Binary Solvent Systems
Ying Guo, Hui He, Haishuang Huang, Jingxuan Qiu, Jiaming Han, Shen Hu, Haoyou Liu, Yue Zhao, Peng Wang
Abstract
The equilibrium solubilities of myo-inositol in five monosolvents (water, methanol, ethanol, isopropanol, acetone) and four binary solvent systems (water + methanol, water + ethanol, water + isopropanol, water + acetone) were determined using the static gravimetric method from 283.15 to 323.15 K under the ambient pressure of 98.8 kPa. The KAT-LSER model was used to perform the multiple linear regression analysis on mixed solvent systems to reveal the solvent effect on solubility. The Hansen solubility parameter was employed to reveal the solubility behavior of myo-inositol. Three thermodynamic models, including the modified Apelblat, Jouyban–Acree, and Apelblat–Jouyban–Acree models, were employed for fitting the solubility data.