Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets
John C. Kostyak, Benjamin Mauri, Carol Dangelmaier, Hymavathi Reddy Vari, Akruti Patel, Monica Wright, Haritha Reddy, Alexander Y. Tsygankov, Satya P. Kunapuli
Abstract
injury was prolonged in Syk Y342F mice. These data demonstrate that phosphorylation of Y342 on Syk following stimulation of either GPVI or CLEC-2 receptors is important for the ability of Syk to transduce a signal.
Topics & Concepts
SykGPVIPhosphorylationPlatelet activationTyrosine phosphorylationCell biologyChemistryImmunoreceptor tyrosine-based activation motifSignal transductionPlatelet membrane glycoproteinReceptorPlateletTyrosine kinaseBiochemistryBiologyImmunologyPlatelet Disorders and TreatmentsMast cells and histamineAutoimmune Bullous Skin Diseases