Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors
Sindhu Carmen Sivakumaren, Hyeseok Shim, Tinghu Zhang, Fleur M. Ferguson, Mark R. Lundquist, Christopher M. Browne, Hyuk‐Soo Seo, Marcia N. Paddock, Theresa Manz, Baishan Jiang, Mingfeng Hao, Pranav Krishnan, Diana G. Wang, Tong Yang, Nicholas Kwiatkowski, Scott B. Ficarro, James M. Cunningham, Jarrod A. Marto, Sirano Dhe‐Paganon, Lewis C. Cantley, Nathanael S. Gray
Topics & Concepts
KinomeAutophagyKinaseDrug discoveryBiologyCell biologyCancerSmall moleculeCancer researchDownregulation and upregulationCancer cellComputational biologyGeneChemistryBiochemistryGeneticsApoptosisAutophagy in Disease and TherapyBiochemical and Molecular ResearchUbiquitin and proteasome pathways