LAG-3 expression on peripheral blood cells identifies patients with poorer outcomes after immune checkpoint blockade
Ronglai Shen, Michael A. Postow, Matthew Adamow, Arshi Arora, Margaret Hannum, Colleen Maher, Phillip Wong, Michael A. Curran, Travis J. Hollmann, Liwei Jia, Hikmat Al‐Ahmadie, Niamh M. Keegan, Samuel A. Funt, Gopa Iyer, Jonathan E. Rosenberg, Dean F. Bajorin, Paul B. Chapman, Alexander N. Shoushtari, Allison Betof Warner, Parisa Momtaz, Taha Merghoub, Jedd D. Wolchok, Katherine S. Panageas, Margaret K. Callahan
Abstract
immunotype detects patients who are less likely to benefit from ICB and suggests a strategy for identifying actionable immune targets for further investigation.
Topics & Concepts
BlockadeMedicineImmune checkpointPeripheralPeripheral bloodImmune systemCD8ImmunotherapyCancer immunotherapyImmunologyOncologyInternal medicineReceptorCancer Immunotherapy and BiomarkersImmune cells in cancerCancer, Stress, Anesthesia, and Immune Response