Genomic Diversity of Azole-Resistant Aspergillus fumigatus in the United States
Kizee A. Etienne, Elizabeth L. Berkow, Lalitha Gade, Natalie S. Nunnally, Shawn R. Lockhart, Karlyn D. Beer, I. King Jordan, Lavanya Rishishwar, Anastasia P. Litvintseva
Abstract
Aspergillus fumigatus is one of the most common causes of invasive mold infections in patients with immune deficiencies and has also been reported in patients with severe influenza and severe acute respiratory syndrome coronavirus 2 (SARs-CoV-2). Triazole drugs are the first line of therapy for this infection; however, their efficacy has been compromised by the emergence of azole resistance in A. fumigatus , which was proposed to be selected for by exposure to azole fungicides in the environment [P.
Topics & Concepts
Aspergillus fumigatusBiologyGeneticsGenomeGenetic diversityAlleleAzoleGeneMicrobiologyAntifungalMedicinePopulationEnvironmental healthAntifungal resistance and susceptibilityFungal Infections and StudiesInfectious Diseases and Mycology