Absolute configuration determination of pharmaceutical crystalline powders by MicroED <i>via</i> chiral salt formation
Bo Wang, Jessica F. Bruhn, Asmerom O. Weldeab, Timothy S. Wilson, Philip T. McGilvray, Michael Mashore, Qiong Song, Giovanna Scapin, Yiqing Lin
Abstract
One can confidently assign the absolute configuration of a chiral molecule using crystalline powders, via microcrystal electron diffraction (MicroED) analysis.
Topics & Concepts
Salt (chemistry)Absolute configurationMaterials scienceChemistryNanotechnologyCrystallographyStereochemistryOrganic chemistryMolecular spectroscopy and chiralityAnalytical Chemistry and ChromatographyCrystallization and Solubility Studies