A solvent-free and efficient synthesis of bicyclic 2-pyridone derivatives for endoplasmic reticulum imaging
Xiao‐Yun Ran, Qian Zhou, Jin Zhang, Shanqiang Wang, Gui Wang, Hui Ying Yang, Xiaochun Liu, Zhouyu Wang, Xiao‐Qi Yu
Abstract
A solvent-free method was developed for the synthesis of bicyclic 2-pyridone (DHIP) derivatives, which demonstrated excellent endoplasmic reticulum (ER) targeting and antibacterial activity after a slight structure regulation.
Topics & Concepts
Endoplasmic reticulumChemistryBicyclic moleculeSolventCombinatorial chemistryStereochemistryOrganic chemistryBiochemistryAdvanced biosensing and bioanalysis techniquesCalcium signaling and nucleotide metabolismBiosensors and Analytical Detection