Melatonin and metformin ameliorated trastuzumab-induced cardiotoxicity through the modulation of mitochondrial function and dynamics without reducing its anticancer efficacy
Apiwan Arinno, Chayodom Maneechote, Thawatchai Khuanjing, Nanthip Prathumsap, Titikorn Chunchai, Busarin Arunsak, Wichwara Nawara, Sasiwan Kerdphoo, Krekwit Shinlapawittayatorn, Siriporn C. Chattipakorn, Nipon Chattipakorn
Topics & Concepts
CardiotoxicityTrastuzumabMedicineMelatoninMetforminCardioprotectionPharmacologyOxidative stressCardiac function curveAutophagyInternal medicineEjection fractionEndocrinologyApoptosisChemotherapyCancerMyocardial infarctionHeart failureChemistryBreast cancerBiochemistryInsulinChemotherapy-induced cardiotoxicity and mitigationMetabolism, Diabetes, and CancerHER2/EGFR in Cancer Research