Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents
Ahmed M. Shawky, Nashwa A. Ibrahim, Ashraf N. Abdalla, Mohammed A. S. Abourehab, Ahmed M. Gouda
Abstract
towards tubulin and CDK-2.
Topics & Concepts
CytotoxicityDocking (animal)ChemistryMoietyCytotoxic T cellStereochemistryTubulinKinaseCell cycle checkpointBenzamideApoptosisCell cycleCancer cellBiochemistryIn vitroMicrotubuleBiologyCell biologyCancerGeneticsNursingMedicineBioactive Compounds and Antitumor AgentsSynthesis and biological activityCancer therapeutics and mechanisms