Effective Treatment of Glioblastoma Multiforme With Oncolytic Virotherapy: A Case-Series
Benjamin Gesundheit, Eliel Ben-David, Yehudit Posen, Ronald D. Ellis, Guido Wollmann, E. Marion Schneider, Karl Reinhard Aigner, Lars Brauns, Thomas Neßelhut, Ingrid Ackva, Christine Weisslein, Arno Thaller
Abstract
Glioblastoma multiforme (GBM) remains an incurable condition, associated with a median survival time of 15 months with best standard of care and 5-year survival rate of <10%. We report on four GBM patients on combination treatment regimens that included oncolytic virus (OV) immunotherapy, who achieved clinical and radiological responses with long-term survival, thus far, of up to 14 years, and good quality of life. We discuss the radiological findings that provide new insights into this treatment, the scientific rationale of this innovative and promising therapy, and considerations for future research.