Engineering Programmed Death Ligand-1/Cytotoxic T-Lymphocyte-Associated Antigen-4 Dual-Targeting Nanovesicles for Immunosuppressive Therapy in Transplantation
Zhanxue Xu, Hsiang‐i Tsai, Youmei Xiao, Yingyi Wu, Dandan Su, Min Yang, Hualian Zha, Fuxia Yan, Xiaoyan Liu, Fang Cheng, Hongbo Chen
Abstract
T cells and cytokine production, enriched regulatory T cells, and prolonged the survival of mouse skin and heart grafts. Taken together, these data supported the idea that PD-L1/CTLA-4 dual-targeting NVs exert immune inhibitory effects and may be used as a prospective immunosuppressant in organ transplantation.
Topics & Concepts
CD80Cytotoxic T cellImmune systemTransplantationImmunologyBiologyT cellDendritic cellCD8Cancer researchCD86Cell biologyMedicineIn vitroCD40Internal medicineBiochemistryExtracellular vesicles in diseaseImmunotherapy and Immune ResponsesImmune Cell Function and Interaction