Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates
Hanjie Jiang, Claire Y Chiang, Zan Chen, Sara Nathan, Gabriel D. D’Agostino, João A. Paulo, Guang Song, Heng Zhu, Sandra B. Gabelli, Philip A. Cole
Abstract
transfection. These studies suggest that WWP2-mediated ubiquitination of the autophagy receptors NDP52, OPTN, and SQSTM1 may positively contribute to the regulation of autophagy.
Topics & Concepts
Ubiquitin ligaseUbiquitinBiologyAutophagyCell biologyBiochemistryMolecular biologyGeneApoptosisUbiquitin and proteasome pathwaysAutophagy in Disease and TherapyCellular transport and secretion