UPR <sup>ER</sup> promotes lipophagy independent of chaperones to extend life span
Joseph R. Daniele, Ryo Higuchi‐Sanabria, Jenni Durieux, Samira Monshietehadi, Vidhya Ramachandran, Sarah U. Tronnes, Naame Kelet, Melissa Sanchez, Melissa G. Metcalf, Gilberto Garcia, Phillip A. Frankino, Camila Benitez, Mandy Zeng, Daniel J. Esping, Larry Joe, Andrew Dillin
Abstract
, is sufficient to deplete lipids, remodel ER, and promote life span. Therefore, UPR induction in neurons triggers two distinct programs in the periphery: the proteostasis arm through protein chaperones and metabolic changes through lipid depletion mediated by EH domain binding protein 1 (EHBP-1).
Topics & Concepts
Endoplasmic reticulumLife spanUnfolded protein responseCell biologyStress (linguistics)HyperactivationChemistryBiologyEvolutionary biologyLinguisticsPhilosophyEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms