Tuning the anticancer properties of Pt(<scp>ii</scp>) complexes <i>via</i> structurally flexible <i>N</i>-(2-picolyl)salicylimine ligands
Kamelah S. Alrashdi, Bandar A. Babgi, Ehab M. M. Ali, Bambar Davaasuren, Abdesslem Jedidi, Abdul‐Hamid Emwas, Maymounah Alrayyani, Mariusz Jaremko, Mark G. Humphrey, Mostafa A. Hussien
Abstract
was investigated and compared to that of cisplatin; the change in the cell accumulation patterns supports the presumption of an apoptotic cell death pathway. The optimized structures of the B-DNA trimer adducts with the platinum complexes showed hydrogen-bonding interactions between the ligands and nucleobases, affecting the inter-strand hydrogen bonding within the DNA, and highlighting the strong ability of the complexes to induce conformational changes in the DNA, leading to the activation of apoptotic cell death. In summary, the current study demonstrates promising new anticancer platinum(ii) complexes with highly flexible tridentate ligands; the functional groups on the ligands are important in tuning their DNA binding/anticancer properties.