Recent Progress in Catalytic Synthesis of 1,2,3-Triazoles
Antonio De Nino, Loredana Maiuolo, Paola Costanzo, Vincenzo Algieri, Antonio Jiritano, Fabrizio Olivito, Matteo Antonio Tallarida
Abstract
1,2,3-triazoles represent a functional heterocyclic core that has been at the center of modern organic chemistry since the beginning of click chemistry. Being a versatile framework, such an aromatic ring can be observed in uncountable molecules useful in medicine and photochemistry, just to name a few. This review summarizes the progress achieved in their synthesis from 2015 to today, with particular emphasis on the development of new catalytic and eco-compatible approaches. In doing so, we subdivided the report based on their degree of functionalization and, for each subparagraph, we outlined the role of the catalyst employed.