<i>Limosilactobacillus reuteri</i> and <i>Lacticaseibacillus rhamnosus GG</i> differentially affect gut microbes and metabolites in mice with Treg deficiency
Yuying Liu, Thomas K. Hoang, Christopher M. Taylor, Evelyn S. Park, Jasmin Freeborn, Meng Luo, Stefan Roos, J. Marc Rhoads
2021American Journal of Physiology-Gastrointestinal and Liver Physiology30 citationsDOIOpen Access PDF
Abstract
In the treatment of Treg-deficiency-induced autoimmunity, Limosilactobacillus reuteri DSM 17938 (LR) showed greater efficacy than Lacticaseibacillus rhamnosus GG (LGG). The study demonstrated that two different probiotics produce distinct signatures in the fecal microbial community in mice with Treg deficiency, but with many similarities in global plasma metabolites in general. However, there are strain-specific microbial products with different anti-inflammatory properties, reinforcing the concept that “one size does not fit all” in the treatment of autoimmune disease.
Topics & Concepts
Lactobacillus reuteriAutoimmunityImmunologyBiologyLactobacillus rhamnosusMicrobiologyDiseaseImmune systemProbioticMedicineBacteriaInternal medicineGeneticsGastrointestinal motility and disordersGut microbiota and healthProbiotics and Fermented Foods