Integrated analysis of single-cell and bulk transcriptomics develops a robust neuroendocrine cell-intrinsic signature to predict prostate cancer progression
Tingting Zhang, Faming Zhao, Yahang Lin, Mingsheng Liu, Hongqing Zhou, Fengzhen Cui, Jin Yang, Liang Chen, Xia Sheng
Abstract
The present study furnishes a valuable tool for the identification of NEPC and the monitoring of PCa progression through transcriptomic profiles obtained from both bulk and single-cell sources.
Topics & Concepts
Prostate cancerComputational biologyIdentification (biology)TranscriptomeGene signatureCancerBiologyComputer scienceGeneGene expressionGeneticsBotanyProstate Cancer Treatment and ResearchCancer Immunotherapy and BiomarkersFerroptosis and cancer prognosis