Astrocytic SIRT6 is a potential anti-depression and anti-anxiety target
Kaiqiang Hu, Huiling Chen, Yuqi Gao, Rui Hua, Xiaojin Shi, Liyuan Li, Yuemiao Yin, Chenye Zeng, Qingfei Liu, Ying Qiu, Zhao Wang
Topics & Concepts
Tail suspension testOpen fieldKnockout mouseBehavioural despair testSirtuinCyclic adenosine monophosphateSIRT6Elevated plus mazeSIRT2AstrocyteConditional gene knockoutEndocrinologyNeuroscienceBiologyInternal medicinePsychologyAnxietyMedicineAntidepressantHippocampusPhenotypePsychiatryBiochemistryCentral nervous systemReceptorGeneAcetylationSirtuins and Resveratrol in MedicineTryptophan and brain disordersBiochemical effects in animals