Engineering an alcohol dehydrogenase with enhanced activity and stereoselectivity toward diaryl ketones: reduction of steric hindrance and change of the stereocontrol element
Kai Wu, Zhijun Yang, Xiangguo Meng, Rong Chen, Jiankun Huang, Lei Shao
Abstract
Engineering an alcohol dehydrogenase with enhanced activity and stereoselectivity toward diaryl ketones: reduction of steric hindrance and change of the stereocontrol element.
Topics & Concepts
Steric effectsStereoselectivityChemistryAlcohol dehydrogenaseAlcoholReduction (mathematics)CatalysisCombinatorial chemistryStereochemistryOrganic chemistryMathematicsGeometryEnzyme Catalysis and ImmobilizationMicrobial Metabolic Engineering and BioproductionPharmacogenetics and Drug Metabolism