Photoinduced Synthesis of Thiocyanates through Hydrogen Atom Transfer and One-Pot Derivatization to Isothiocyanates
Bumpei Maeda, Yusuke Aihara, Ayato Sato, Toshinori Kinoshita, Kei Murakami
Abstract
Photoinduced benzylic C-H thiocyanation is described. A series of alkyl thiocyanates were efficiently obtained by using Selectfluor as the oxidant. Moreover, we accomplished the one-pot isothiocyanation following the C-H thiocyanation. The thiocyanates and isothiocyanates were applied to the divergent transformation of pharmaceuticals.
Topics & Concepts
ChemistryHydrogen atomDerivatizationAlkylSelectfluorPhotoinduced electron transferPhotochemistryTransformation (genetics)Combinatorial chemistryOrganic chemistryElectron transferCatalysisHigh-performance liquid chromatographyBiochemistryGeneSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsSynthesis and Catalytic Reactions