<scp>Long‐term</scp> normothermic perfusion of human livers for longer than 12 days
Ngee‐Soon Lau, Mark Ly, Claude V. Dennis, Ken Liu, James G. Kench, Michael Crawford, Carlo Pulitanò
Abstract
In this case report, we preserved human livers for up to 13 days under normothermic conditions using a modified commercial perfusion system. Two whole livers were split into two left lateral segment grafts and two extended right grafts without interruption to blood flow and then perfused on separate machines. Not only does this provide the basis for a meaningful study of liver function in the long term, but this could also facilitate the development of a model of ex situ liver regeneration.
Topics & Concepts
PerfusionTerm (time)Blood flowMachine perfusionMedicineSurgeryCardiologyLiver transplantationTransplantationPhysicsQuantum mechanicsOrgan Transplantation Techniques and OutcomesLiver physiology and pathologyLiver Disease and Transplantation