Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in <i>Mycobacterium tuberculosis</i>
Shipra Grover, Curtis A. Engelhart, Esther Pérez‐Herrán, Wei Li, Katherine A. Abrahams, Kadamba Papavinasasundaram, James Bean, Christopher M. Sassetti, Alfonso Mendoza-Losana, Gurdyal S. Besra, Mary Jackson, Dirk Schnappinger
Abstract
oxidase as one class of off-target hits in whole-cell screens for MmpL3 inhibitors and report a novel sulfanylacetamide as a potential QcrB inhibitor.
Topics & Concepts
Mycobacterium tuberculosisBiochemistryBiologyFunction (biology)CellCell biologyChemistryTuberculosisPathologyMedicineTuberculosis Research and EpidemiologyMycobacterium research and diagnosisBacterial Genetics and Biotechnology