Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase
Rabia Ramzan, Bernhard Kadenbach, Sebastian Vogt
Abstract
Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still found in cyanobacteria, but not in other bacteria. Therefore the "allosteric ATP inhibition of COX" is described here in more detail. Most regulatory properties of COX are related to "supernumerary" subunits, which are largely absent in bacterial COX. The "allosteric ATP inhibition of COX" was also recently described in intact isolated rat heart mitochondria.
Topics & Concepts
Allosteric regulationCytochrome c oxidaseMitochondrionAdenosine triphosphateBiochemistryEnzymeHeme AChemistryATP synthaseBiologyCell biologyMitochondrial Function and PathologyPhotosynthetic Processes and MechanismsATP Synthase and ATPases Research