Nicotine exacerbates atherosclerosis and plaque instability via NLRP3 inflammasome activation in vascular smooth muscle cells
Junqing An, Liu Ouyang, Changjiang Yu, Sean Carr, Tharmarajan Ramprasath, Zhixue Liu, Ping Song, Ming-Hui Zou, Ding Ye
Abstract
Nicotine promotes atherosclerotic plaque instability by lysosomal dysfunction-mediated NLRP3 inflammasome activation in vascular smooth muscle cells.
Topics & Concepts
InflammasomeVascular smooth muscleNicotineElectrical impedance myographyMedicineInternal medicineChemistryEndocrinologyInflammationSmooth muscleVasodilationInflammasome and immune disordersAtherosclerosis and Cardiovascular DiseasesCalcium signaling and nucleotide metabolism