N-substituted phthalimide–carboxylic acid hybrids as dual-targeted aldose reductase inhibitors: Synthesis, mechanistic insights, and cancer-relevant profiling
Blinera Zognjani, Arleta Rifati Nixha, Hatice Esra Duran, Mustafa Arslan, Gizem Yıldıztekin, Abdulilah Ece, Cüneyt Türkeş
Topics & Concepts
ChemistryAldose reductasePhthalimideBiochemistryCombinatorial chemistryAldose reductase inhibitorComputational biologyEnzymeStereochemistryBiologyAldose Reductase and TaurineEnzyme function and inhibitionCancer, Hypoxia, and Metabolism