Hedgehog-inspired immunomagnetic beads for high-efficient capture and release of exosomes
Jia Cheng, Nanhang Zhu, Yujia Zhang, Yue Yu, Ke Kang, Qiangying Yi, Yao Wu
Abstract
Encountered with the immunomagnetic hedgehog particles, exosomes were positively selected with an exosomal marker (CD63) and negatively selected by depleting environmental pollutants (protein precipitates, cell debris) with the TiO 2 nanospikes.
Topics & Concepts
MicrovesiclesHedgehogCD63Cell biologyNanotechnologyMaterials scienceChemistryBiophysicsBiologymicroRNABiochemistrySignal transductionGeneExtracellular vesicles in diseaseGold and Silver Nanoparticles Synthesis and ApplicationsLattice Boltzmann Simulation Studies