Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors
Hao‐Yue Xiang, Jian-Yang Chen, Xia‐Juan Huan, Yi Chen, Zhaobing Gao, Jian Ding, Ze‐Hong Miao, Chunhao Yang
Topics & Concepts
PyridazineChemistryPoly ADP ribose polymeraseStereochemistryCell growthStructure–activity relationshipChemical synthesisCombinatorial chemistryIn vitroBiochemistryEnzymePolymerasePARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisToxin Mechanisms and Immunotoxins