Cdc7-mediated phosphorylation of Cse4 regulates high-fidelity chromosome segregation in budding yeast
Prashant Mishra, Henry N. Wood, John Stanton, Wei-Chun Au, Jessica R. Eisenstatt, Lars Boeckmann, Robert A. Sclafani, Michael Weinreich, Kerry Bloom, Peter H. Thorpe, Munira A. Basrai
Abstract
) with Cse4 at the kinetochore leads to growth defects. Moreover, phospho-deficient mutations of Cse4 for consensus Cdc7 target sites contribute to CIN phenotype. In summary, our results have defined a role for Cdc7-mediated phosphorylation of Cse4 in faithful chromosome segregation.
Topics & Concepts
Chromosome segregationBiologyCell biologyChromosome instabilityPhosphorylationGeneticsChromosomeGeneMicrotubule and mitosis dynamicsDNA Repair MechanismsFungal and yeast genetics research