Fabrication and characterization of wound dressings containing gentamicin/silver for wounds in diabetes mellitus patients
Xinyu Bie, Muhammad Qamar Khan, Azeem Ullah, Sana Ullah, Davood Kharaghani, Duy‐Nam Phan, Yasushi Tamada, Ick Soo Kim
Abstract
Abstract In this study, the dual functional wound dressings for diabetic patients were fabricated with the help of gentamicin/ cellulose acetate by electrospinning. The resultant nanofibers were functionalized with silver nanoparticles (AgNPs) on its surface by a simple facile wetting process. Herein, gentamicin (Ge) was used for the objective to heal the infection inflammation and Ag NPs were loaded for the antibacterial properties. The resultant CA/Ge/Ag nanofibers were characterized for morphology analysis, chemical interactions examination, release behavior, structure analysis and antibacterial efficiency by scan electron microscope/ transmission electron microscope, FTIR/XPS, ICP study, XRD study and disc diffusion method of antibacterial, respectively. Based on characterization results it was concluded that all samples of CA/Ge/Ag nanofibers showed the antibacterial properties and appreciable release behavior.