Luteolin enhances drug chemosensitivity by downregulating the FAK/PI3K/AKT pathway in paclitaxel‑resistant esophageal squamous cell carcinoma
Zhenzhen Yang, Hongtao Liu, Yinsen Song, Na Gao, Pan Gao, Yiran Hui, Yueheng Li, Tianli Fan
Abstract
. Luteolin enhanced drug chemosensitivity by downregulating the FAK/PI3K/AKT pathway in PTX‑resistant ESCC and could be a promising agent for the treatment of PTX‑resistant ESCC cancers.
Topics & Concepts
PaclitaxelOncogeneCancer researchEsophageal squamous cell carcinomaPI3K/AKT/mTOR pathwayCell cycleApoptosisMolecular medicineOncologyCellMedicineProtein kinase BBasal cellCell growthChemotherapyInternal medicineCarcinomaBiologyCancerBiochemistryGeneticsCancer, Lipids, and MetabolismLung Cancer Treatments and MutationsEsophageal Cancer Research and Treatment