Co-delivery of autophagy inhibitor and gemcitabine using a pH-activatable core-shell nanobomb inhibits pancreatic cancer progression and metastasis
Xiaoxiao Chen, Tao Yuan, Manmin He, Miao Deng, Rong Guo, Qinglin Sheng, Xuhui Wang, Kebai Ren, Ting Li, Xuan He, Shuya Zang, Zhirong Zhang, Man Li, Qin He
Abstract
The pH-sensitive PDGL-GEM@CAP/CQ shows potential for inhibiting proliferation and metastasis of pancreatic cancer through an autophagy-dependent pathway.
Topics & Concepts
AutophagyGemcitabinePancreatic cancerCancer researchMetastasisChemistryInternalizationPancreatic tumorCytotoxicityDrug deliveryGrowth inhibitionIn vitroCancerCellMedicineApoptosisInternal medicineBiochemistryOrganic chemistryAutophagy in Disease and TherapyNanoparticle-Based Drug DeliveryCancer Research and Treatments