<i>Hippophae rhamnoides</i> L. leaf extracts alleviate diabetic nephropathy <i>via</i> attenuation of advanced glycation end product-induced oxidative stress in db/db mice
Min Ji Gu, Hee-Weon Lee, Guijae Yoo, Donghwan Kim, Yoonsook Kim, In‐Wook Choi, Youn‐Soo Cha, Sang Keun Ha
Abstract
for 12 weeks to db/db mice. Histological changes and the urine albumin/creatinine ratio were relieved, and the accumulation of AGEs in kidney glomeruli decreased following SBL treatment. Moreover, the SBL extract reduced the expression of AGEs, the receptor for AGEs, and NADPH oxidase 4, but upregulated glyoxalase 1 in the diabetic renal tissue. Urinary excretion levels and expression of 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative stress decreased after SBL treatment in the renal tissue. Furthermore, SBL attenuated oxidative stress in diabetic kidneys by reducing AGE accumulation, thereby ameliorating renal damage. Therefore, from these results, we infer that the SBL extract can act as a potential therapeutic agent for diabetic renal complications caused by AGEs.