Recent advances in nanogels for drug delivery and biomedical applications
Arti Vashist, Arti Vashist, Gabriela Perez Alvarez, Vianessa Andion Camargo, Andrea Raymond, Adriana Yndart, Nagesh Kolishetti, Atul Vashist, Atul Vashist, Pandiaraj Manickam, Saurabh Aggarwal, Madhavan Nair
Abstract
Nanotechnology has shown great promise for researchers to develop efficient nanocarriers for better therapy, imaging, and sustained release of drugs. The existing treatments are accompanied by serious toxicity limitations, leading to severe side effects, multiple drug resistance, and off-target activity. In this regard, nanogels have garnered significant attention for their multi-functional role combining advanced therapeutics with imaging in a single platform. Nanogels can be functionalized to target specific tissues which can improve the efficiency of drug delivery and other challenges associated with the existing nanocarriers. Translation of nanogel technology requires more exploration towards stability and enhanced efficiency. In this review, we present the advances and challenges related to nanogels for cancer therapy, ophthalmology, neurological disorders, tuberculosis, wound healing, and anti-viral applications. A perspective on recent research trends of nanogels for translation to clinics is also discussed.