PatchDock and SymmDock: servers for rigid and symmetric docking
Dina Schneidman‐Duhovny, Yoel Inbar, Ruth Nussinov, Haim J. Wolfson
Abstract
Here, we describe two freely available web servers for molecular docking. The PatchDock method performs structure prediction of protein-protein and protein-small molecule complexes. The SymmDock method predicts the structure of a homomultimer with cyclic symmetry given the structure of the monomeric unit. The inputs to the servers are either protein PDB codes or uploaded protein structures. The services are available at http://bioinfo3d.cs.tau.ac.il. The methods behind the servers are very efficient, allowing large-scale docking experiments.
Topics & Concepts
ServerDocking (animal)UploadWeb serverBiologyProtein Data Bank (RCSB PDB)Protein structureComputational biologyComputer scienceCrystallographyThe InternetOperating systemBiochemistryChemistryNursingMedicineComputational Drug Discovery MethodsProtein Structure and DynamicsEnzyme Structure and Function